|
KMID : 1102220190380040517
|
|
Kidney Research and Clinical Practice
2019 Volume.38 No. 4 p.517 ~ p.524
|
|
|
Clinical features and outcomes in kidney transplant recipients with renal cell carcinoma: a single-center study
|
|
Park Keun-Hoi
Yoon Jung-A
Kim Hak-Soo
Kim Hyo-Sang
Park Su-Kil
Kim Young-Hoon
Hong Bum-Sik
You Dal-San
Jeong In-Gab
Baek Chung-Hee
|
|
|
Abstract
|
|
|
Background: Previous studies have recommended a 2- to 5-year waiting time prior to kidney transplantation (KT) in patients with end-stage renal disease (ESRD) and symptomatic renal cell carcinoma (RCC) and no delay for incidental early-stage RCC. Data on Asian KT recipients are unavailable.
Methods: This is a Korean single-center retrospective study on 35 KT recipients with ESRD and RCC. Patients were classified into two groups: early KT (KT performed within 1 year after nephrectomy for RCC, including KT with simultaneous nephrectomy) and delayed KT (KT performed over than 1 year after nephrectomy for RCC). Patient survival, graft survival, and cancer recurrence were compared between both groups.
Results: There were no statistically significant differences in patient survival (P = 0.388), graft survival (P = 0.317), or graft rejection rate (P = 0.207) between the early and delayed KT groups. Additionally, there were no differences in pathological characteristics or RCC stage other than cancer histology: acquired cystic disease-associated RCC (47.4%) was the most common RCC type in the early KT group, whereas clear cell type (62.5%) was the most common RCC type in the delayed KT group. No RCC recurrence was observed.
Conclusion: Patients with early-stage and asymptomatic RCC do not require a mandatory observational period prior to KT after curative nephrectomy.
|
|
|
KEYWORD
|
|
|
End-stage renal disease, Kidney transplantation, Recurrence, Renal cell carcinoma, Survival
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|